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Not so tough

Not so tough

作者:门涡蛑  时间:2019-03-07 04:08:02  人气:

THE ulcer and cancer-causing gut bacterium, Helicobacter pylori, has an Achilles’ heel. Scientists have long been intrigued by how this tough bug thrives in the acidity of the stomach. They assumed that urease, an enzyme found on its surface, broke down urea to produce ammonia—which neutralised the acid. Now George Sachs and his colleagues at the University of California at Los Angeles have discovered that it’s not the urease on the surface but urease inside the cell that neutralises the acid. And a protein, UreI, on the cell’s inner membrane acts as gatekeeper,